PDB: 4RUM
Cobalt bound complex of NiCo riboswitch

PDB: 3PDR
Manganese bound complex of M-box riboswitch

PDB: 2NVO
Ro protein from D. radiodurans

PDB: 2HH7
Copper sensing transcriptional
regulator from M. tuberculosis

​Research articles and Reviews

17. Anirudh Chakravarthy, Anirudh K N, Geen George, Shyamsundar Ranganathan, Nishan Shettigar, Suchitta U, Dasaradhi Palakodeti, Akash Gulyani, Arati Ramesh. "Engineered RNA sensors for ultrasensitive SARSCoV2 detection in a simple color or luminescence assay" Life Science Alliance. 2021 Sep; 4 (12) e202101213; DOI: 10.26508/lsa.202101213
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16. Dolly Mehta and Arati Ramesh. “Diversity and prevalence of ANTAR RNAs across actinobacteria” BMC Microbiology. 21, 159 (2021). DIO: 10.1186/s12866-021-02234-x

15. Kushi Anand, Ashutosh Tripathi, Kaustubh Shukla, Nitish Malhotra, Anilkumar Jamithireddy, Rajiv Kumar Jha, Susmit Narayan Chaudhury, Raju S Rajmani, Arati Ramesh, Valakunja Nagaraja, Balasubramanian Gopal, Ganesh Nagaraju, Aswin Sai Narain Seshayee, Amit Singh. “Mycobacterium tuberculosis SufR responds to nitric oxide via its 4Fe–4S cluster and regulates Fe–S cluster biogenesis for persistence in mice” Redox Biology. 46 (2021) 102062.

14. Siladitya Bandyopadhyay, Susmitnarayan Chaudhury, Dolly Mehta and Arati Ramesh. “Discovery of iron-sensing bacterial riboswitches” Nature Chemical Biology, Oct 2020. https://doi.org/10.1038/s41589-020-00665-7. NOTE: We have retracted this publication


13. Mehta D*, Anjali K* and Ramesh A. "Discovery of ANTAR-RNAs and their mechanism of action in mycobacteria." Journal of Molecular Biology. 2020 Jun; 432(14), 4032-48. *Co-first authors. 

12. Michelle Ninochka D'Souza, Naveen Kumar, Chandappa Gowda, Vishal Tiwari, Rosana Ottakandathil Babu, Praveen Anand, Sudhriti Ghosh Dastidar, Randhir Singh, Bhuvaneish Selvaraja, Rakhi Pal, Arati Ramesh, Sumantra Chattarji, Siddharthan Chandran, Akash Gulyani, Dasaradhi Palakodeti, and Ravi S. Muddashetty. “FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation” iScience, 2018, 9, 399-411.

11. Ramesh A. "Second messenger-sensing riboswitches in bacteria." Semin. Cell Dev. Biol. 2015 Dec; Vol 47-48, 3-8.

10. Furukawa K*, Ramesh A*, Zhou Z*, Weinberg Z, Vallery T, Winkler W.C, Breaker R.R. "Bacterial riboswitches cooperatively bind Ni(2+) or Co(2+) ions and control expression of heavy metal transporters." Mol. Cell. 2015 Mar; Vol 57, 1088-1098. *Co-first authors
Featured as Editor's choice in Sci. Signal. Vol.8, Issue 371.

9. DebRoy S, Gebbie M, Ramesh A, Goodson J.R, Cruz M.R, Van Hoof A, Winkler W.C and Garsin D.A. “A riboswitch-containing sRNA controls gene expression by sequestration of a response regulator.” Science.  2014 Aug; 345(6199), 937-40.
Comment by Chen J. and Gottesman S. in Science

8. Ramesh A and Winkler W.C. “Metabolite-binding ribozymes”. BBA Gene Regulatory Mechanisms. 2014 Oct; 1839(10):989-994.  

7. Ramesh A*, DebRoy S*, Goodson J.R, Fox K.A, Faz H, Garsin D.A, Winkler W.C. “The mechanism for RNA recognition by ANTAR regulators of gene expression”. PLoS Genetics. 2012 June; 8(6). *Co-first authors
Perspective by Stewart V. and van Tilbeurgh H. in PLoS Genetics.

6. Ramesh A*, Wakeman C.A. and Winkler W.C*. “Insights into metalloregulation by the M-box riboswitch” J. Mol. Biol. 2011 Apr; 8 (407), 556-570. *Co-corresponding authors

5. Ramesh A and Winkler W.C. “Magnesium sensing riboswitches in bacteria”.  RNA Biology 2010 Jan; 7(77-83).

4. Wakeman C.A, Ramesh A, Winkler W.C. “Multiple metal-binding cores are required for metalloregulation by M-box riboswitch RNAs.” J. Mol. Biol. 2009; 392(3):723-35.

3. Fox KA*, Ramesh A*, Stearns JE, Bourgogne A, Reyes-Jara A, Winkler WC, Garsin DA. “Multiple posttranscriptional regulatory mechanisms partner to control ethanolamine utilization in Enterococcus faecalis.” Proc. Natl. Acad. Sci. 2009; 106(11):4435-40. *Co-first authors

2. Ramesh A, Savva CG, Holzenburg A, Sacchettini JC. “Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity.” J. Biol. Chem. 2007; 282(20): 14960-7.

1. Liu T*, Ramesh A*, Ma Z, Ward SK, Zhang L, George GN, Talaat AM, Sacchettini JC, Giedroc DP. “CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.” Nature Chem. Biol. 2007 Jan; 3(1):60-8. *co-first authors
Faculty of 1000 recommended
Comment by Wilmot C.M, in Nature Chem. Biol.
Featured on C&EN (Chemical and Engineering News), 2006